Clinically Proven to Significantly Enhance Cognitive Function, Reduce the Effects of Depression, Anxiety, and ADHD, and Improve Learning Outcomes

Developed by World-leading Neuroscientists at Yale University

Below you will find 30 peer-reviewed research papers published in leading scientific journals that were authored by C8’s founder, Dr. Bruce Wexler and his colleagues at Yale University School of Medicine and around the world. These papers describe the technology that underlies our products and the successful clinical trials that have been run using the cognitive exercises in our products such as the “catch the ball” exercises that were the primary component of the intervention in the depression trials.

Blue text is for Adult Brain Health articles

Red Text is for Child Brain Health and Learning articles


Aida Bikic, Søren Dalsgaard, Brian Pittman, James Frederick Leckmang and Bruce Wexler Cognitive training for children with ADHD: Composite cognitive score outcome in a randomized controlled trial Nordic Journal of Psychiatry (in press)

Bruce E. Wexler, Ryan Kish Using Micro-Cognition Biomarkers of Neurosystem Dysfunction to Define ADHD Subtypes: A Scalable Digital Path to Diagnosis Based on Brain Function. Psychiatry Research 326 (2023) 115348


Min Shu, Suyang Feng, Jiacheng Liu Targeting disrupted rich-club network organization with neuroplasticity-based computerized cognitive remediation in major depressive disorder patients. Psychiatry Research 316 (2022) 114742

Westwood, S. J., Bozhilova, N., Criaud, M., Lam, S-L., Lukito, S., Wallace-Hanlon, S., Kowalczyk, O. S., Kostara, A., Mathew, J., Wexler, B. E., Cohen Kadosh, R., Asherson, P., & Rubia, K. The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: a double-blind, randomized, sham-controlled trial. IBRO Neuroscience Reports 2022 12:55-64.

Wexler BE. Returning to basic principles to develop more effective treatments for central nervous system disorders. Experimental Biology and Medicine 2022 1-12 DOI: 10.1177/1535370221078291.


Wexler B. Opinion Mental Health: Digital neuroscience can help alleviate the mental health crisis. The Financial Times London April 23, 2021.

Westwood, S. J., Criaud, M., Lam, S-L., Lukito, S., Wallace-Hanlon, S., Kowalczyk, O. S., Kostara, A., Mathew, J., Agbedjro, D., Wexler, B. E., Cohen Kadosh, R., Asherson, P., & Rubia, K. Transcranial direct current stimulation (tDCS) combined with cognitive training in adolescent boys with ADHD: a double-blind, randomized, sham-controlled trial. Psychological Medicine 2021 1-16.


Hawn G, Wexler B. OPINION: Why policymakers and school leaders can’t ignore how the pandemic hurts childhood brain development. The Hechinger Report August 28, 2020.

Morimoto S, Altizer R, Gunning F, Liu J, Cote S, Nitis J, Alexopoulos G. May 2020 Targeting Cognitive Control Deficits With Neuroplasticity-Based Computerized Cognitive Remediation in Patients With Geriatric Major Depression: A Randomized, Doble-Blind, Controlled Trial. The American Journal of Geriatric Psychiatry

Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz, H, Dong J, Leckman JF. (2020: 1-12): An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Psychological Medicine

Wexler BE, Imal AE, Pittman B, Bell MB. (2020 11: 1-14): Executive function deficits mediate poverty’s effects on academic achievement: Target for intervention in at-risk children. Creative Education

Imal AE, O’Leary S, Wexler BE.: Identification of maladaptive risk-taking patterns and associated cognitive weaknesses in children: An opportunity for primary-prevention of negative health outcomes from high-risk behaviors in adolescence? Psychiatric Research and Clinical Practice 2020 doi:10.1176/appi.prcp.2020.20190020.


Kavanaugh B, Tuncer O, Wexler BE. (2019 3: 271-280): Measuring and Improving Executive Function in the Classroom. J of Cognitive Enhancement

Surti TS, Vinogradov, S, Bell MD, Wexler BE. (2019 doi: 10.1016/j.schres.2019.11.021): Improvement on visual cognitive training exercises in schizophrenia is present but less robust than in healthy individuals. Schizophrenia Research

Bell MD, Imal AE, Pittman B, Wexler BE. (2019 17: 100120): The development of adaptive risk taking and the role of executive functions in a large sample of school-age boys and girls. Trends in Neuroscience and Education Science Direct

Smith SS, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. (2019: 278: 248-257): Effects of a brain, body and social (IBBS), intervention on ERP measures of attentional control on children with ADHD. Psychiatry Research



Corbera, S., Wexler, B.E., Poltorak, A., Thime, W.R., Kurtz, M.M. (2017:247:21-27): Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research.


Wexler, B. E. et al. (2016, 6, 32859; doi: 10.1038/srep32859): Cognitive Priming and Cognitive Training: Immediate and FarTransfer to Academic Skills in Children. Nature Scientific Reports


Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. (August 5, 2014): Neuroplasticity-based computerized cognitive remediation for treatment resistant geriatric depression. Nature Communications

Morris D. Bell, Kee-Hong Choi, Christina Dyer, Bruce E. Wexler. (April, 2014): Benefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning. Psychiatric Services


Wexler BE.(2013: 5:1-17): Integrated Brain and Body Exercises for ADHD and Related Problems with Attention and Executive Function. International Journal of Gaming and Computer-Mediated Simulations



Kurtz MM. Seltzer JC. Fujimoto M. Shagan DS. Wexler BE. (2009: 107:267-74.): Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research


Bell MD, Zito W, Greig T, Wexler BE (2008: 105:18-29): Neurocognitive Enhancement Therapy with Vocational Services in Schizophrenia: Work Outcomes at Two Year Follow-Up. Schizophrenia Research


Kurtz, M.M., Seltzer, J.C., Shagan, D.S., Thime, W.R., Wexler, B.E. (2007:89:251-260): Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient? Schizophrenia Research

Bell, M, Fiszdon, J, Greig, T, Wexler, BE, Bryson, G. (2007:44:761-770): Neurocognitive enhancement therapy with work therapy in schizophrenia: A 6-month follow-up of neuropsychological performance. Journal of Rehabilitation Research and Development

Greig TC. Zito W. Wexler BE. Fiszdon J. Bell MD. (2007: 96(1-3):156-61): Improved cognitive function in schizophrenia after one year of cognitive training and vocational services. Schizophrenia Research


Fiszdon, J, Whelahan, H., Bryson. G., Silverstein, S., Wexler, B., Bell, M. (2005, 112:187-193): Cognitive Training of Verbal Memory Using a Dichotic Listening Paradigm: Impact on Symptoms and Cognition in Schizophrenia. Acta Psychiatrica Scandinavia

Kurtz, M.M., Seltzer, J.C., Shagan, D.S., Wexler, B.E. (2005, 31(2): 330-330): Neurocognitive remediation for patients with schizophrenia: How specific is the intervention and its effects? Schizophrenia Bulletin

Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. (2005, 31(2): 518-519): Functional outcomes from a RCT of cognitive training and work therapy: 12 month follow-up. Schizophrenia Bulletin

Bryson GJ, Bell MD, Greig TC, Wexler BE. (2005, 31(2): 520-521): Neuropsychological outcomes from a RCT of cognitive training and work therapy: 12 month follow-up. Schizophrenia Bulletin

Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. (2005, 42:829-838): Neurocognitive Enhancement Therapy with Work Therapy: Productivity Outcomes at 6 and 12 month follow-up. Journal of Rehabilitation Research and Development

Wexler, BE, Bell MD. (2005, 31(4):931-941): Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin


Fiszdon JM, Bryson GJ, Wexler BE, Bell MD. (2004, 125:1-7): Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up. Psychiatry Research

Bell MD, Fiszdon J, Bryson G, Wexler BE. (2004, 9:199-211): Effects of neurocognitive enhancement therapy in schizophrenia: Normalisation of memory performance. Cognitive Neuropsychiatry



Bell M, Bryson G, Tasamine Greig, PhD, Cheryl Corcoran, MD, Wexler BE (2001, 58:763-768): Neurocognitive enhancement therapy with work therapy: Effects on neuropsychological test performance. Archives of General Psychiatry


Wexler BE, Anderson M, Fulbright RK, Gore JC.(2000, 157:1094-1097): Improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. American Journal of Psychiatry


Wexler BE, Hawkins KA, Rounsaville B, Anderson M, Sernyak MJ, Green MF (1997, 26: 173-180): Normal neurocognitive performance after extended practice in patients with schizophrenia. Schizophrenia Research